hidusb.sys is the default Windows driver for ALL USB keyboard/mouse/joystick/gamepad devices. Deleting it is not advisable but if you want to screw things up by all means continue to delete things out of the System32 folder. When Windows itself is putting files back after you delete them that means you’re doing something wrong.
I would like to assume you’ve installed the correct drivers for your mouse but you didn’t say you did. Download and install the intellipoint drivers from here:
http://www.microsoft.com/hardware/mouseand…d/download.mspx
If that doesn’t fix it, scan your core Windows files to ensure they are not corrupt.
Go to Start->Run. Type “SFC /scannow” and hit ok. This will take some time.
More to follow if it doesn’t help.