Nades were gone because of nade spamming. Soldier, Spy, Demo, and any long range gun can take out a turret. Spy has the best way of taking them out with his sapper charges.
If you wanna take out those medics + heavy just get a soldier and a demoman on em. Wanna make sure you get them put medics on the demo/soldier.
I personally like being able to walk out of spawn without 50 grenades up my *edited* ^^.
I wish the medic could still spread aids.
I have no problem with what they have done and I think the only class that needs work is the sniper, out of any class it is the only one that I believe is weak.
No need to conc jump if you can double jump instead 
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I’ve really enjoyed most of the new maps and think they chose the right theme for the game. Definitely worth every penny.
gonzo said:
I played for about half an hour today. It looks great. I love the cell shading they did on all of the textures. Gameplay-wise I don’t like it that much. It seemed very hard to kill someone in the game, although I was only Heavy and Demo. Medics seem to ruin the game for me because they would just stand next to one big person and heal they faster than I could kill them. The only real reason I bought this was for portal and that isn’t out yet so I wouldn’t say it’s a waste of money.
It was my experience that the heavy could rip thru most classes easily as long as u aim properly. The only classes that it can’t rip to shreds are the soldier/heavy. If he has medics, kill his medics and get out of the way while your medics heal you 
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Playing the engineer and spy I didn’t once think ‘wow this is too hard to kill.’ I guess it just depends.
If you played the demo, he is the most explosive character in the game… When I played him I was killing groups of people fairly easily (until those pesky spies got me).
It is a great teamwork oriented game that really has improved upon a winning formula. It isn’t perfect but its definitely better than 90% of the other crap out there.